Ghosh M, McCulloch C
Can J Ophthalmol. 1978 Apr;13(2):110-9.
A case of epithelial corneal degeneration that was first seen as a pigmented plaque but changed to a whrol-like pattern and then partially regressed is described. The pathologic abnormality was an intra-cellular inclusion of lipid in the basal cells and of lipid and mucopolysaccharide in the wing and superficial cells. No duplication of basement membrane or thickening of Bowman's layer was present. It is suggested that despite different origins the pathologic entity in this case, in Fabry's disease and in chloroquine keratopathy is similar. The whorled pattern is due to a sliding of the corneal epithelial cells as they rise from the basal cells to the surface, much as a cyclonic flow forms about an atmospheric low in the southern hemisphere.
本文描述了一例上皮性角膜变性病例，最初表现为色素沉着斑块，随后转变为涡状形态，之后部分消退。病理异常表现为基底细胞内有脂质包涵体，翼状细胞和表层细胞内有脂质和黏多糖包涵体。未见基底膜重复或Bowman层增厚。提示尽管起源不同，但该病例、法布里病和氯喹角膜病变中的病理实体相似。涡状形态是由于角膜上皮细胞从基底细胞向表面上升时发生滑动所致，类似于南半球围绕大气低压形成的气旋性气流。
