Kobayashi S, Kasuya M, Ishii Y, Takehana M, Sakai K, Suzuki N, Itoi M
Kyoritsu College of Pharmacy, Tokyo, Japan.
Curr Eye Res. 1992 Nov;11(11):1099-103. doi: 10.3109/02713689209015081.
The effect of 2-mercaptopropionylglycine on the development of cataract induced by a single dose of X-ray (10 Gy) was investigated in rats. Intraperitoneal injection of 20 mg/kg, three times weekly starting 1 day after irradiation delayed the development of X-ray-induced cataracts significantly. The amounts of non-protein SH groups, malondialdehyde and the Na+/K+ ratio, in the lenses of rats post-treated with the drug were significantly maintained at normal levels even at 27 weeks after irradiation. On the other hand, a single administration of 250 mg/kg of the compound, 30 min prior to irradiation had no effect on cataract progression induced by X-ray.
研究了2-巯基丙酰甘氨酸对单次剂量X射线（10 Gy）诱导大鼠白内障形成的影响。在照射后1天开始，每周三次腹腔注射20 mg/kg，显著延迟了X射线诱导的白内障的形成。即使在照射后27周，用该药物后处理的大鼠晶状体中的非蛋白巯基、丙二醛含量和Na+/K+比值仍显著维持在正常水平。另一方面，在照射前30分钟单次给予250 mg/kg该化合物，对X射线诱导的白内障进展没有影响。
