Rizzari C, Conter V, Jankovic M, D'Angelo P, Masera G, Costantini D, Bettinelli M E, Giunta A M
Dipartimento di Ematologia Pediatrica, Università di Milano, Ospedale San Gerardo, Monza, Italy.
Haematologica. 1992 Sep-Oct;77(5):427-9.
The association of cystic fibrosis (CF) and acute lymphoblastic leukaemia (ALL) is extremely rare. Only three cases have been reported in the literature and all of them had a fatal outcome. In this paper we describe the case of a little girl who was diagnosed with CF (mild course) when she was five months old, and who presented at the age of five years with ALL (intermediate risk). Complete Remission (CR) was rapidly obtained with standard chemotherapy for ALL.; treatment was continued for two years without major complications and with no apparent influence on the course of CF. The patient remains alive and well and in continuous CR four years after discontinuing treatment, and six years after the diagnosis of ALL.
囊性纤维化（CF）与急性淋巴细胞白血病（ALL）的关联极为罕见。文献中仅报道过3例，且均预后不良。本文描述了一名小女孩的病例，她在5个月大时被诊断为CF（病情较轻），5岁时患ALL（中危）。采用ALL的标准化疗迅速实现了完全缓解（CR）；治疗持续了两年，未出现重大并发症，对CF病程也无明显影响。在停止治疗四年后，即诊断出ALL六年之后，患者仍然健在且处于持续CR状态。
