Wang T H, Hung P T, Ho T C
Department of Ophthalmology, National Taiwan University Hospital, Taipei.
J Ocul Pharmacol. 1992 Winter;8(4):325-32. doi: 10.1089/jop.1992.8.325.
We performed sclerostomy using THC:YAG laser (thulium, holmium, chromium doped YAG crystal) and subconjunctival injection of mitomycin soon after the filtering process in rabbits to observe the lowering effect of intraocular pressure(IOP) and filtering bleb formation. A 1-mm conjunctiva wound was made 12 mm away from the sclerostomy site to allow the entry of the optic probe for delivering energy. Forty-eight rabbits were divided into 3 groups. After sclerostomy, Group I received 0.2 ml normal saline subconjunctival injection and Group II and III received 0.2 ml mitomycin injection of 0.1 and 0.2 mg/ml respectively. One eye of each rabbit was randomly selected for the experiment while the fellow eye served as control. The bleb lasted 1.4 +/- 0.5 days (or 1 to 2 days) in Group I, 8.5 +/- 4.5 days (or 4 to 17 days) in Group II and 15.4 +/- 10.9 days (or 4 to 37 days) in Group III. The IOP lowering effect was significantly enhanced in Group III. The postoperative complication was minimal corneal punctate erosion in the mitomycin group, but all of them, however, resolved within one week. The results demonstrated that mitomycin is effective in prolonging the filtering effect produced by the THC:YAG laser.
我们在兔眼滤过术后立即使用钬钇铝石榴石激光（掺铥、钬、铬的钇铝石榴石晶体）进行巩膜造口术，并结膜下注射丝裂霉素，以观察眼压（IOP）降低效果和滤过泡形成情况。在距巩膜造口部位12毫米处制作一个1毫米的结膜伤口，以便光学探头进入以传递能量。48只兔分为3组。巩膜造口术后，I组结膜下注射0.2毫升生理盐水，II组和III组分别结膜下注射0.2毫升浓度为0.1毫克/毫升和0.2毫克/毫升的丝裂霉素。每只兔随机选择一只眼进行实验，另一只眼作为对照。I组滤过泡持续1.4±0.5天（或1至2天），II组为8.5±4.5天（或4至17天），III组为15.4±10.9天（或4至37天）。III组眼压降低效果显著增强。丝裂霉素组术后并发症为轻度角膜点状糜烂，但均在一周内痊愈。结果表明，丝裂霉素可有效延长钬钇铝石榴石激光产生的滤过效果。
