颈动脉化学感受器刺激对犬股薄肌、肾血流量及肾功能的主要影响。

Primary effects of carotid chemoreceptor stimulation on gracilis muscle and renal blood flow and renal function in dogs.

作者信息

al-Obaidi M, Karim F

机构信息

Department of Physiology, University of Leeds.

出版信息

J Physiol. 1992 Sep;455:73-88. doi: 10.1113/jphysiol.1992.sp019291.

DOI:10.1113/jphysiol.1992.sp019291

PMID:1484369

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1175634/

Abstract

In chloralose-anaesthetized and artificially ventilated dogs, the carotid sinus regions were vascularly isolated and perfused either with arterial or mixed (arterial and venous) blood (partial pressure of O2 (PO2) 43.8 +/- 2.4 mmHg, mean +/- S.E.M. n = 14) to stimulate the carotid chemoreceptors. The carotid sinus pressure was held constant at 142.0 +/- 2.8 mmHg. Measurements were made of renal and gracilis muscle blood flow by wrap-round electromagnetic flow probes placed around the renal and gracilis arteries, glomerular filtration rate by creatine clearance, urinary sodium excretion by flame photometry and solute excretion by osmometry. 2. In ten dogs, with intact cervical vagosympathetic trunks, carotid chemoreceptor stimulation produced significant increases in aortic pressure (AoP) of 12.7 +/- 1.1% (n = 10, P < 0.001), in glomerular filtration rate (GFR) of 14.7 +/- 4.1% (P < 0.001), urine flow rate (V) of 16.5 +/- 3.5% (P < 0.002), in urinary sodium excretion (UNaV) of 17.5 +/- 2.5% (P < 0.005) and in urinary osmolar excretion (UosmV) of 13.2 +/- 2.2% (P < 0.001), but a significant decrease in renal blood flow (RBF) of 5.8 +/- 1.8% (P < 0.02). In six of these dogs in which gracilis muscle blood flow (MBF) was also recorded, carotid chemoreceptor stimulation caused significant increases in AoP of 12.8 +/- 1.4% (n = 6, P < 0.001) and in MBF of 10.0 +/- 1.6% (P < 0.002), and a small but significant decrease in RBF of 3.6 +/- 1.5% (P < 0.02). 3. In fourteen dogs, with sectioned cervical vagosympathetic trunks, carotid chemoreceptor stimulation produced increases in AoP of 22.0 +/- 2.6% (n = 14, P < 0.001), in GFR of 36.9 +/- 4.2% (P < 0.001), in V of 30.1 +/- 4.4% (P < 0.001), in UNaV of 31.4 +/- 5.3% (P < 0.001), and in UosmV of 25.7 +/- 5.8% (P < 0.001). However, it produced a greater decrease in RBF of 10.5 +/- 1.9% (P < 0.001). In ten of these dogs, where MBF was recorded, carotid chemoreceptor stimulation caused greater increase in AoP of 22.4 +/- 3.0% (n = 10, P < 0.001) and in MBF of 32.8 +/- 3.7% (P < 0.001), and a greater decrease in RBF of 9.8 +/- 1.9% (P < 0.001).(ABSTRACT TRUNCATED AT 400 WORDS)

摘要

在用氯醛糖麻醉并进行人工通气的犬中，将颈动脉窦区域进行血管分离，并用动脉血或混合血（动脉血和静脉血，氧分压（PO2）43.8±2.4 mmHg，均值±标准误，n = 14）灌注以刺激颈动脉化学感受器。颈动脉窦压力维持在142.0±2.8 mmHg。通过环绕在肾动脉和股薄肌动脉周围的电磁血流探头测量肾和股薄肌的血流，通过肌酐清除率测量肾小球滤过率，通过火焰光度法测量尿钠排泄，通过渗透压测定法测量溶质排泄。2. 在10只颈迷走交感干完整的犬中，刺激颈动脉化学感受器使主动脉压（AoP）显著升高12.7±1.1%（n = 10，P < 0.001），肾小球滤过率（GFR）升高14.7±4.1%（P < 0.001），尿流率（V）升高16.5±3.5%（P < 0.002），尿钠排泄（UNaV）升高17.5±2.5%（P < 0.005），尿渗透压排泄（UosmV）升高13.2±2.2%（P < 0.001），但肾血流量（RBF）显著降低5.8±1.8%（P < 0.02）。在其中6只也记录了股薄肌血流（MBF）的犬中，刺激颈动脉化学感受器使AoP显著升高12.8±1.4%（n = 6，P < 0.001），MBF升高10.0±1.6%（P < 0.002），RBF有小幅但显著的降低3.6±1.5%（P < 0.02）。3. 在14只颈迷走交感干切断的犬中，刺激颈动脉化学感受器使AoP升高22.0±2.6%（n = 14，P < 0.001），GFR升高36.9±4.2%（P < 0.001），V升高30.1±4.4%（P < 0.001），UNaV升高31.4±5.3%（P < 0.001），UosmV升高25.7±5.8%（P < 0.001）。然而，它使RBF有更大幅度的降低，为10.5±1.9%（P < 0.001）。在其中10只记录了MBF的犬中，刺激颈动脉化学感受器使AoP有更大幅度的升高，为22.4±3.0%（n = 10，P < 0.001），MBF升高32.8±3.7%（P < 0.001），RBF有更大幅度的降低，为9.8±1.9%（P < 0.001）。（摘要截断于400字）