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[麻风病与遗传。一位地区医生在1884年的思考]

[Leprosy and heredity. Reflections of a district physician in 1884].

作者信息

Sandvik H

机构信息

Seksjon for allmennmedisin Institutt for samfunnsmedisinske fag Universitetet i Bergen.

出版信息

Tidsskr Nor Laegeforen. 1992 Dec 10;112(30):3799-801.

PMID:1485295
Abstract

During the 19th century leprosy was a serious health problem in Norway, especially in some western, rural districts. In 1856 it was decided that all leprous patients should be examined by the local doctor (District Health Officer), and registered in a national leprosy register. The patients' family relationships received special attention. Some patients tried to avoid registration, fearing that the data might be misused. After Armauer Hansen (1841-1912) discovered in 1873 that leprosy was an infectious disease, isolation of leprous patients was enforced. In 1884 Thomas Collett (1835-1898), the local doctor in a rural district of western Norway, carried out a survey of all leprous patients registered in his district, a total of 164 patients. The data from his survey provide convincing support for the view that hereditary factors play an important role in the development of the disease. Modern research has confirmed that an important gene controls the susceptibility to leprosy.

摘要

在19世纪,麻风病在挪威是一个严重的健康问题,尤其是在一些西部农村地区。1856年,决定由当地医生(地区卫生官员)对所有麻风病人进行检查,并登记在国家麻风病登记簿上。病人的家庭关系受到特别关注。一些病人试图避免登记,担心这些数据可能被滥用。1873年阿马尔·汉森(1841 - 1912)发现麻风病是一种传染病后,麻风病人被强制隔离。1884年,挪威西部一个农村地区的当地医生托马斯·科利特(1835 - 1898)对他所在地区登记的所有麻风病人进行了调查,共有164名病人。他的调查数据为遗传因素在该疾病发展中起重要作用这一观点提供了令人信服的支持。现代研究已经证实,一个重要基因控制着对麻风病的易感性。

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