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非精原细胞瘤性睾丸肿瘤的“监测”。对100例疾病一期患者的前瞻性研究

["Surveillance" of non-seminomatous testicular tumors. A prospective study of 100 patients in the first stage of illness].

作者信息

Hornák M, Zvara V, Ondrus D

机构信息

Clinique d'Urologie, Dérer Hôpital, Bratislava, Tchécoslovaquie.

出版信息

Ann Urol (Paris). 1992;26(5):306-10.

PMID:1485800
Abstract

In a prospective study, 100 patients with clinical stage I nonseminomatous testicular tumours were investigated by a surveillance policy, which consisted of regular follow-up after orchiectomy alone until disease progression was confirmed. Follow-up revealed that 65 of the 100 patients were free of disease at 25 to 90 months after orchiectomy. Disease progression was detected in 35 patients at 3 to 27 months following orchiectomy. Patients with progression were treated by PVB chemotherapy. Patients with non-seminomatous testicular tumours in clinical stage I represent a group which is not homogeneous and can therefore not be treated by means of a single modality. It is necessary to individually define optimal treatment based on prognostic factors. The surveillance policy is available in patients without risk factors and regular follow-up is mandatory. Multidisciplinary collaboration and cooperation with patients are essential.

摘要

在一项前瞻性研究中,对100例临床I期非精原细胞瘤性睾丸肿瘤患者采用监测策略进行研究,该策略包括仅在睾丸切除术后进行定期随访,直至证实疾病进展。随访结果显示,100例患者中有65例在睾丸切除术后25至90个月无疾病。35例患者在睾丸切除术后3至27个月检测到疾病进展。进展患者接受PVB化疗。临床I期非精原细胞瘤性睾丸肿瘤患者并非同质化群体,因此不能采用单一治疗方式。有必要根据预后因素个体化确定最佳治疗方案。无危险因素的患者可采用监测策略,定期随访是必需的。多学科协作以及与患者的合作至关重要。

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