Leong V Y, Brown T P
Department of Avian Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602.
Avian Dis. 1992 Oct-Dec;36(4):1102-6.
A commercial broiler company experienced a sudden increase of mortality in four flocks at two separate locations. Affected houses had red dust on inside walls and on the equipment. Affected chickens were 10 to 18 days old. Grossly, chickens had pale, swollen kidneys, dark-brown enlarged livers, and urates in joint spaces. Histologically, the kidneys had multifocal proximal tubular necrosis, the livers had dilated sinusoids, biliary hyperplasia, and accumulation of brown pigment in hepatocytes and bile ducts. One starter ration was analyzed, and it contained 6500 mg ethoxyquin/kg. The red dust in the houses and the brown pigment in livers were interpreted to be ethoxyquin. Clinical signs and histologic lesions were reproduced experimentally with 12,500 mg ethoxyquin/kg feed.
一家商业肉鸡公司在两个不同地点的四个鸡群中突然出现死亡率上升的情况。受影响的鸡舍内墙和设备上有红色粉尘。受影响的鸡龄为10至18天。大体上，鸡的肾脏苍白、肿大，肝脏呈深褐色且肿大，关节间隙有尿酸盐沉积。组织学上，肾脏有多灶性近端肾小管坏死，肝脏有窦状隙扩张、胆管增生，肝细胞和胆管中有褐色色素蓄积。对一种雏鸡日粮进行了分析，其乙氧喹含量为6500毫克/千克。鸡舍中的红色粉尘和肝脏中的褐色色素被认为是乙氧喹。用含12500毫克乙氧喹/千克饲料进行实验，再现了临床症状和组织学病变。
