Bauer M S, Soloway A, Dratman M B, Kreider M
Department of Veterans Affairs Medical Center, Providence, RI 02908-4799.
Biol Psychiatry. 1992 Sep 1;32(5):411-25. doi: 10.1016/0006-3223(92)90129-n.
Male rats made hypothyroid by administration of propylthiouracil plus sodium ipodate in drinking water were compared to controls in terms of period of circadian activity and temperature rhythms, amount of gross motor activity, and mean temperature. Animals were studied under entrainment, constant darkness (DD), and constant dim light (LL). There was no difference in the period of the circadian activity rhythm between groups in DD. However, hypothyroid rats showed significant blunting of the period-lengthening response to increasing ambient illumination. As expected, the period of the circadian temperature rhythm increased in controls with increasing ambient illumination. In contrast, the period of the circadian temperature rhythm in hypothyroid animals actually shortened under LL compared to DD. This blunting of the period-lengthening response to increasing ambient illumination of both activity and temperature rhythms in hypothyroid animals could not be explained by differences in activity level or mean temperature between the groups.
将通过在饮用水中给予丙硫氧嘧啶加碘番酸钠使雄性大鼠甲状腺功能减退，并将其与对照组在昼夜活动周期和温度节律、总体运动活动量以及平均温度方面进行比较。在同步化、持续黑暗（DD）和持续弱光（LL）条件下对动物进行研究。在DD条件下，各组之间昼夜活动节律的周期没有差异。然而，甲状腺功能减退的大鼠对环境光照增加的周期延长反应明显减弱。正如预期的那样，随着环境光照增加，对照组的昼夜温度节律周期延长。相比之下，与DD相比，甲状腺功能减退动物在LL条件下昼夜温度节律的周期实际上缩短了。甲状腺功能减退动物对环境光照增加的活动和温度节律的周期延长反应减弱，无法用各组之间的活动水平或平均温度差异来解释。
