核丝氨酸/苏氨酸蛋白激酶DNA依赖性蛋白激酶
The nuclear serine/threonine protein kinase DNA-PK.
作者信息
Anderson C W, Lees-Miller S P
机构信息
Biology Department, Brookhaven National Laboratory, Upton, NY 11973.
出版信息
Crit Rev Eukaryot Gene Expr. 1992;2(4):283-314.
PMID:1486241
Abstract
The DNA-activated protein kinase (DNA-PK) is a nuclear serine/threonine protein kinase that phosphorylates DNA-binding proteins, including several transcription factors. DNA-PK is one of a very few enzymes known to be regulated through interaction with DNA that does not have DNA as a template or substrate. We suggest that DNA-PK may function in cell homeostasis, in part through the modulation of transcriptional activity.
摘要
DNA激活蛋白激酶（DNA-PK）是一种核丝氨酸/苏氨酸蛋白激酶，可磷酸化包括几种转录因子在内的DNA结合蛋白。DNA-PK是已知的极少数通过与DNA相互作用进行调节的酶之一，这种相互作用不以DNA为模板或底物。我们认为，DNA-PK可能在细胞稳态中发挥作用，部分是通过调节转录活性来实现的。
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