Hizawa N, Yamaguchi E, Ohe M, Itoh A, Furuya K, Ohnuma N, Kawakami Y
First Department of Medicine, School of Medicine, Hokkaido University, Sapporo, Japan.
Clin Exp Allergy. 1992 Dec;22(12):1065-9. doi: 10.1111/j.1365-2222.1992.tb00131.x.
Atopy as defined in terms of IgE responsiveness was reported to be controlled by a single gene in British families, and this concept was further supported by a significant linkage between atopy and restriction fragment length polymorphism (RFLP) detected by a DNA probe specific to chromosome 11q13. To confirm this observation in a Japanese population, segregation and linkage analyses were done in four large families. Although segregation patterns of atopy were in agreement with the pattern of autosomal dominant inheritance, there was no significant linkage between atopy and locus 11q13. Alterations in the definitions of atopy did not affect the results. These findings suggested the presence of heterogeneity in genetic elements of atopy, even though atopy may be determined mainly by a single dominant gene.
据报道，在英国家庭中，以IgE反应性定义的特应性受单个基因控制，并且这一概念得到了特应性与11q13染色体特异性DNA探针检测到的限制性片段长度多态性（RFLP）之间显著连锁的进一步支持。为了在日本人群中证实这一观察结果，对四个大家庭进行了分离分析和连锁分析。尽管特应性的分离模式与常染色体显性遗传模式一致，但特应性与11q13位点之间没有显著连锁。特应性定义的改变并未影响结果。这些发现表明，即使特应性可能主要由单个显性基因决定，其遗传因素中也存在异质性。
