脂肪肉瘤中的染色体异常。

Chromosome abnormalities in liposarcomas.

作者信息

Ohjimi Y, Iwasaki H, Kaneko Y, Ishiguro M, Ohgami A, Fujita C, Shinohara N, Yoshitake K, Kikuchi M

机构信息

Department of Pathology, Fukuoka University School of Medicine, Japan.

出版信息

Cancer Genet Cytogenet. 1992 Dec;64(2):111-7. doi: 10.1016/0165-4608(92)90339-a.

DOI:10.1016/0165-4608(92)90339-a

PMID:1486559

Abstract

We performed a cytogenetic study of short-term cultures from fresh surgical specimens obtained from four patients with liposarcoma. Myxoid liposarcomas (cases 1-3) were associated with a specific translocation between chromosomes 12 and 16. Trisomy 8, a nonrandom secondary aberration in myxoid liposarcoma, was observed in the third case as the only additional change. Round cell liposarcoma (case 4) showed complex chromosomal aberrations affecting chromosomes 1, 2, 5, 6, 7, 13, 14, 17, 19, and 22. Neither band 12q13 nor 16p11 was visibly rearranged. Three subgroups of liposarcomas are proposed. The first group is characterized by t(12;16)(q13;p11), the second group by ring chromosomes, telomeric associations, and giant markers, and the last by complex numerical and structural aberrations.

摘要

我们对取自4例脂肪肉瘤患者新鲜手术标本的短期培养物进行了细胞遗传学研究。黏液样脂肪肉瘤（病例1 - 3）与12号和16号染色体之间的特定易位有关。8三体是黏液样脂肪肉瘤中的一种非随机继发性畸变，在第3例中被观察到是唯一的额外变化。圆形细胞脂肪肉瘤（病例4）显示出影响1、2、5、6、7、13、14、17、19和22号染色体的复杂染色体畸变。12q13带和16p11带均未出现明显重排。我们提出了脂肪肉瘤的三个亚组。第一组的特征是t(12;16)(q13;p11)，第二组的特征是环状染色体、端粒联合和巨大标记物，最后一组的特征是复杂的数目和结构畸变。