Altungoz O, Meloni A M, Peier A, Zalupski M, Spanier S, Brooks J S, Sandberg A A
Cancer Center of Southwest Biomedical Research Institute, Scottsdale, Arizona 85251.
Cancer Genet Cytogenet. 1995 Feb;79(2):104-10. doi: 10.1016/0165-4608(94)00180-j.
We report the cytogenetic findings in three mixed liposarcoma following short-term cultures. During the course of cytogenetic investigation of various types of liposarcomas, we observed an interstitial deletion of the long arm of chromosome 6 together with the translocation (12;16)(q13;p11) in three tumors. Translocation (12;16) is associated with myxoid and mixed (myxoid/round cell) liposarcomas, although deletion of chromosome 6 has been observed in only a few of these tumors. Our findings suggest that del(6), as an additional change in myxoid liposarcoma, is probably related to tumor progression.
我们报告了三例经短期培养后的混合型脂肪肉瘤的细胞遗传学研究结果。在对各类脂肪肉瘤进行细胞遗传学研究的过程中，我们在三例肿瘤中观察到6号染色体长臂的间质缺失以及（12；16）（q13；p11）易位。（12；16）易位与黏液样和混合型（黏液样/圆形细胞）脂肪肉瘤相关，尽管在这些肿瘤中仅少数观察到6号染色体缺失。我们的研究结果表明，作为黏液样脂肪肉瘤的一种额外变化，6号染色体缺失可能与肿瘤进展有关。
