费城染色体阳性慢性髓性白血病患者的7号染色体（p11p15）缺失
Deletion (7)(p11p15) in a patient with Philadelphia-positive chronic myelogenous leukemia.
作者信息
Carrasco Juan J L, Otero Gómez A, García Miranda J L, Trujillo González M, Herrera Fernández M, Bello Hernández T
机构信息
Cytogenetics Service, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain.
出版信息
Cancer Genet Cytogenet. 1992 Dec;64(2):142-4. doi: 10.1016/0165-4608(92)90344-8.
PMID:1486563
Abstract
We report a case of chronic myelogenous leukemia (CML) with a Philadelphia (Ph) chromosome. During the transformation phase of the disease, a del(7)(p11p15) and a +Ph were identified as additional chromosomal anomalies. We believe that loss of the segment 7p11-->p15 may play an important role in the progression of the disease.
摘要
我们报告一例伴有费城（Ph）染色体的慢性粒细胞白血病（CML）病例。在疾病转化期，发现一条7号染色体长臂部分缺失[del(7)(p11p15)]和额外的Ph染色体为其他染色体异常。我们认为7号染色体短臂11区至15区片段的缺失可能在疾病进展中起重要作用。
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