Ren Chengzhen, Li Likun, Yang Guang, Timme Terry L, Goltsov Alexei, Ren Chenghui, Ji Xiaorong, Addai Josephine, Luo Hongbin, Ittmann Michael M, Thompson Timothy C
Scott Department of Urology, Baylor College of Medicine, Houston, Texas, USA.
Cancer Res. 2004 Feb 1;64(3):969-76. doi: 10.1158/0008-5472.can-03-2592.
We previously identified and characterized a novel p53-regulated gene in mouse prostate cancer cells that was homologous to a human gene that had been identified in brain cancers and termed RTVP-1 or GLIPR. In this report, we document that the human RTVP-1 gene is also regulated by p53 and induces apoptosis in human prostate cancer cell lines. We show that the expression of the human RTVP-1 gene is down-regulated in human prostate cancer specimens compared with normal human prostate tissue at the mRNA and protein levels. We further document epigenetic changes consistent with RTVP-1 being a tumor suppressor in human prostate cancer.
我们之前在小鼠前列腺癌细胞中鉴定并表征了一个新的p53调控基因，该基因与一个在脑癌中已鉴定出的人类基因同源，被命名为RTVP-1或GLIPR。在本报告中，我们证明人类RTVP-1基因也受p53调控，并能在人类前列腺癌细胞系中诱导凋亡。我们发现，与正常人类前列腺组织相比，人类RTVP-1基因在人类前列腺癌标本中的mRNA和蛋白质水平表达下调。我们进一步证明了与RTVP-1作为人类前列腺癌肿瘤抑制因子相一致的表观遗传变化。
