Ortiz J L, Cortijo J, Vallés J M, Morcillo E J
Departament de Farmacologia, Facultat de Medicina i Odontologia, Universitat València, Spain.
Fundam Clin Pharmacol. 1992;6(6):247-9. doi: 10.1111/j.1472-8206.1992.tb00117.x.
The effects of 3 phosphodiesterase (PDE) inhibitors, rolipram (PDE IV), milrinone (PDE III) and theophylline (non-selective) on PAF (50 ng kg-1; iv)-induced airway vascular leakage have been evaluated in guinea-pigs. Rolipram (3-300 micrograms kg-1; iv) reduced the increase in permeability induced by PAF at all airway levels whereas milrinone (10-1000 micrograms kg-1; iv) and theophylline (30 mg kg-1; iv) were without effects. The anti-leakage activity of rolipram may be of therapeutic value in asthma.
