卡介苗对胸导管淋巴细胞的作用。
The effect of BCG on thoracic duct lymphocytes.
作者信息
Stuhldreher D, Frank W, Shaw M, Muchnik S, Hussein N, Rubenstein M, Guinan P
机构信息
Department of Cellular Biology, Hektoen Institute for Medical Research, Chicago, Illinois.
出版信息
Immunol Invest. 1992 Dec;21(7):613-21. doi: 10.3109/08820139209069397.
Adoptive immunotherapy is becoming increasingly more important in the management of advanced malignancies. This report describes the results of immunomodulation therapy with BCG in the Dunning tumor. In addition it describes new techniques in the harvesting of lymphocytes. Thoracic duct lymphocytes from 34 rats were evaluated for the effect of the presence of the Dunning R-3327 AT-3 tumor as well as for the response to bacillus Calmette Guerin (BCG). Both tumor and BCG resulted in significant changes in the helper/suppressor T cell ratios.
过继性免疫疗法在晚期恶性肿瘤的治疗中变得越来越重要。本报告描述了用卡介苗对邓宁肿瘤进行免疫调节治疗的结果。此外，还描述了淋巴细胞采集的新技术。对34只大鼠的胸导管淋巴细胞进行评估，观察邓宁R-3327 AT-3肿瘤的存在所产生的影响以及对卡介苗（BCG）的反应。肿瘤和卡介苗均导致辅助性/抑制性T细胞比例发生显著变化。
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