Craelius W, Akay M, Tangella M
Department of Biomedical Engineering, Rutgers University, Piscataway, NJ 08855.
Med Biol Eng Comput. 1992 Jul;30(4):385-8. doi: 10.1007/BF02446165.
Autonomic nervous activities are estimated in three groups of patients: Group A consists of patients who had experienced myocardial infarction (MI) within 2-6 weeks before the tests; Group B consists of patients who had MI more than one year previously; Group C consists of matched controls, free of cardiac disease. Autonomic activity is estimated using postural effects on heart rate variability (HRV): a sympathetic activity index is defined as HRV power within a low frequency band (0.04-0.12 Hz) in the tilt position and a parasympathetic activity index is defined as HRV power in a high frequency band (0.18-0.28 Hz) in the supine position. Results show that, relative to controls, Group A patients have reduced parasympathetic activity index (5 + 3 against 13 + 8, normalised units; p < 0.05) and an increased ratio of sympathetic to parasympathetic activity (17 + 17 against 4 + 2; p < 0.05). Group B is not significantly different from Group A or C. The period of 2-6 weeks post-MI thus appears to be characterised by depressed parasympathetic nervous activity which can be measured using HRV analysis.
A组由在测试前2 - 6周内经历过心肌梗死（MI）的患者组成；B组由一年多以前患过心肌梗死的患者组成；C组由匹配的无心脏病对照组组成。利用姿势对心率变异性（HRV）的影响来评估自主神经活动：交感神经活动指数定义为倾斜位时低频带（0.04 - 0.12Hz）内的HRV功率，副交感神经活动指数定义为仰卧位时高频带（0.18 - 0.28Hz）内的HRV功率。结果显示，与对照组相比，A组患者的副交感神经活动指数降低（标准化单位为5 + 3对比13 + 8；p < 0.05），交感神经与副交感神经活动的比率增加（17 + 17对比4 + 2；p < 0.05）。B组与A组或C组无显著差异。因此，心肌梗死后2 - 6周这一时期的特征似乎是副交感神经活动受到抑制，这可以通过HRV分析来测量。
