Jabłońska-Skwiecińska E, Giro E, Rokicka-Milewska R
Zakładu Diagnostyki Laboratoryjnej CMKP, Warszawie.
Acta Haematol Pol. 1992;23(2):123-8.
A therapeutic trial with mannose given intravenously as a 5% solution during 7 consecutive days (daily doses 12.5 g, 25 g and 50 g) was performed in a GPI deficient girl with nonspherocytic hemolytic anemia. The aim of the trial was to substitute glucose--the main red cells metabolic substrate--with mannose, since the glucose metabolism, due to the GPI deficiency, was significantly decreased. An initial good effect of treatment was disturbed with viral infection. No complications due to treatment with mannose were observed.
对一名患有非球形细胞溶血性贫血的糖基磷脂酰肌醇（GPI）缺乏症女孩进行了一项治疗试验，连续7天静脉注射5%的甘露糖溶液（每日剂量分别为12.5克、25克和50克）。该试验的目的是用甘露糖替代葡萄糖（红细胞的主要代谢底物），因为由于GPI缺乏，葡萄糖代谢显著降低。治疗初期的良好效果因病毒感染而受到干扰。未观察到因甘露糖治疗引起的并发症。
