Tariné Gombkŏtö Z, Molnár J, Farkasné Gunics G, Regdon G, Selmeczi B
Szent-Györgyi Albert Orvostudományi Egyetem, Gyógyszertechnológiai Intézet, Szeged.
Acta Pharm Hung. 1992 Nov;62(6):302-9.
After the physical parameters had been determined, the in vitro drug liberation from vaginal suppositories containing 100 mg of antibacterial agent (sulphadimine, chloramphenicol, gentamicin-sulphate) was studied by membrane diffusion and microbiological methods. Among the vehicles available in Hungary the hydrophylic Massa macrogoli was found to be the best for this purpose. Among the lipophilic bases the in vitro drug liberation of the French Suppocire NA product was significantly better (p < 0.05) compared to the other lipophilic bases. This vehicle is recommended by the authors for the topical treatment of vaginitis, as these suppositories have the further advantage that they can easily be produced on a magistral, galenical or industrial scale as well. In the first part of the publication the formulation and some important physical parameters of lipophilic and hydrophilic antibacterial suppositories for vaginal use were described. In the present paper the drug liberation ability of the compositions with proper physical parameters was studied. The published results were obtained from measurements performed 1 week after formulation.
在确定物理参数后，采用膜扩散法和微生物学方法研究了含100mg抗菌剂（磺胺二甲嘧啶、氯霉素、硫酸庆大霉素）的阴道栓的体外药物释放情况。在匈牙利现有的基质中，发现亲水性的聚乙二醇基质最适合此用途。在亲脂性基质中，法国Suppocire NA产品的体外药物释放明显优于其他亲脂性基质（p < 0.05）。作者推荐该基质用于阴道炎的局部治疗，因为这些栓剂还有一个优点，即它们可以很容易地在医院药房、药剂学或工业规模上生产。在该出版物的第一部分中，描述了用于阴道的亲脂性和亲水性抗菌栓剂的配方和一些重要的物理参数。在本文中，研究了具有适当物理参数的组合物的药物释放能力。已发表的结果来自制剂制备1周后进行的测量。
