Regdon G, Gombkötö S, Regdon G, Selmeczi B
Albert Szent-Györgyi Medical University, Department of Pharmaceutical Technology, Szeged, Hungary.
Pharm Acta Helv. 1994 Dec;69(3):141-8. doi: 10.1016/0031-6865(94)90015-9.
Vaginal suppositories frequently used in gynaecological therapy were studied. Several antibacterial pharmacons are used for the topical treatment of vaginitis of various origins. In view of the fact that the liberation of the given active substance and the subsequent therapeutic effect may be improved or inhibited by the vehicle, our aim was to find the optimal suppository base for vaginal suppositories containing sulfadimidine, chloramphenicol and gentamicin sulfate by means of in vitro experiments. On the basis of breaking hardness, disintegration time and spreading properties the French Suppocire NA product, and compositions of macrogols with lower molecular weight proved to be the best lipophilic and hydrophilic bases, respectively. Among the lipophilic bases the in vitro drug liberation of Suppocire NA was significantly better (P < 0.05) than the other lipophilic bases. This vehicle is recommended for the topical treatment of vaginitis, as these suppositories have the further advantage that they can easily be produced on a magistral, galenical or industrial scale as well.
对妇科治疗中常用的阴道栓剂进行了研究。几种抗菌药物用于各种病因阴道炎的局部治疗。鉴于赋形剂可能会促进或抑制特定活性物质的释放及后续治疗效果，我们的目的是通过体外实验找到含磺胺二甲嘧啶、氯霉素和硫酸庆大霉素的阴道栓剂的最佳栓剂基质。基于硬度、崩解时间和铺展性能，法国的Suppocire NA产品以及较低分子量的聚乙二醇组合物分别被证明是最佳的亲脂性和亲水性基质。在亲脂性基质中，Suppocire NA的体外药物释放明显优于其他亲脂性基质（P < 0.05）。这种赋形剂推荐用于阴道炎的局部治疗，因为这些栓剂还有一个优点，即它们可以很容易地在医院药房、药剂学或工业规模上生产。
