Doyle E, Britto J, Freeman J, Munro F, Morton N S
Intensive Care Unit, Royal Hospital for Sick Children, Yorkhill, Glasgow.
Arch Dis Child. 1992 Dec;67(12):1483-4. doi: 10.1136/adc.67.12.1483.
Two cases of vena caval thrombosis in infants were successfully treated with low dose (0.01-0.05 mg/kg/hour) local infusions of tissue plasminogen activator after conventional anticoagulant treatment had been unsuccessful. This approach is useful for clots associated with indwelling intravascular catheters, and a low dose infusion of tissue plasminogen activator as a regional application is recommended to achieve clot lysis with minimal systemic effects.
两例婴儿腔静脉血栓形成患者在常规抗凝治疗失败后，通过低剂量（0.01 - 0.05毫克/千克/小时）局部输注组织型纤溶酶原激活剂成功治愈。这种方法对于与留置血管内导管相关的血栓有效，建议低剂量输注组织型纤溶酶原激活剂进行局部应用，以在全身影响最小的情况下实现血栓溶解。
