Sathe S, Wong J, Warren R, Hunt D
Department of Cardiology, Royal Melbourne Hospital, Vic., Australia.
Aust N Z J Med. 1992 Dec;22(6):647-51. doi: 10.1111/j.1445-5994.1992.tb04864.x.
The purpose of this study was to evaluate the immediate and long-term clinical and haemodynamic effects of Percutaneous Balloon Aortic Valvuloplasty (PBAV). Thirty-three procedures were performed in 27 patients, 11 males and 16 females with a mean age of 72 years. The peak to peak systolic gradient across the aortic valve decreased by 52%, from 67 +/- 24 mmHg to 31 +/- 15 mmHg (p < 0.0001) and the aortic valve area increased by 35%, from 0.48 +/- 0.16 to 0.67 +/- 0.21 cm2 (p < 0.001) after PBAV. There were no procedural deaths. Minor complications occurred in seven patients. Eighty-one per cent of patients (27 procedures) showed immediate symptomatic improvement, five remained symptomatic and one died in hospital before discharge. In a mean follow-up of 17 +/- 12 months (range six to 38 months), eight patients died due to congestive cardiac failure, six underwent repeat PBAV, three died due to noncardiac causes and three had recurrent symptoms controlled on medical therapy. Event free survival at 15 months was 43%. In conclusion PBAV produces a satisfactory immediate clinical and haemodynamic result, however, considering the high rate of symptom recurrence, this procedure has a beneficial role only in short-term palliation of severely symptomatic patients who are unable to undergo aortic valve replacement.
本研究的目的是评估经皮气囊主动脉瓣成形术(PBAV)的即刻和长期临床及血流动力学效果。对27例患者实施了33例手术,其中男性11例,女性16例,平均年龄72岁。PBAV术后,主动脉瓣跨瓣收缩期峰-峰压差降低了52%,从67±24 mmHg降至31±15 mmHg(p<0.0001),主动脉瓣面积增加了35%,从0.48±0.16 cm²增至0.67±0.21 cm²(p<0.001)。无手术死亡病例。7例患者出现轻微并发症。81%的患者(27例手术)即刻症状改善,5例仍有症状,1例在出院前死于医院。平均随访17±12个月(6至38个月),8例患者死于充血性心力衰竭,6例接受了重复PBAV,3例死于非心脏原因,3例经药物治疗控制了复发症状。15个月时无事件生存率为43%。总之,PBAV产生了令人满意的即刻临床和血流动力学结果,然而,考虑到症状复发率较高,该手术仅对无法接受主动脉瓣置换的重症有症状患者的短期姑息治疗有有益作用。