Hellerich U, Budde R
Institut für Rechtsmedizin, Albert-Ludwigs-Universität Freiburg.
Beitr Gerichtl Med. 1992;50:69-74.
Histological evaluation of bone marrow in 30 autopsy cases with a history of chronic alcohol consumption revealed characteristic changes concerning the medullary iron distribution and, first and foremost, the erythropoiesis, which was found to be macroblastic. These autoptic findings reflected the pattern of alcoholic dyshematopoiesis resulting from a toxic effect of alcohol on the bone marrow, well-known from biopsies and aspirates of alcohol-dependent patients and combined with hemochromatosis-associated plasma cell iron in the marrow and elevation of median corpuscular volume of erythrocytes in the peripheral blood. Therefore, this stereotyped morphological findings in the bone marrow of autopsy cases extend the well-known scope of alcohol-induced pathological organ changes.
对30例有长期饮酒史的尸检病例的骨髓进行组织学评估，发现其骨髓铁分布存在特征性变化，最重要的是红细胞生成出现巨幼红细胞性改变。这些尸检结果反映了酒精对骨髓的毒性作用所导致的酒精性造血异常模式，这在酒精依赖患者的活检和穿刺检查中是众所周知的，同时伴有骨髓中与血色素沉着症相关的浆细胞铁沉积以及外周血中红细胞平均体积升高。因此，尸检病例骨髓中这种刻板的形态学发现扩展了已知的酒精诱导的病理性器官变化范围。
