Wilde C J, Kerr M A, Knight C H, Racey P A, Burnett A
Hannah Research Institute, Ayr.
Exp Physiol. 1992 Nov;77(6):873-9. doi: 10.1113/expphysiol.1992.sp003654.
Mammary cell differentiation was measured in lactating pipistrelle bats (Pipistrellus pipistrellus) by assay of key enzyme activities, and by determination of protein and lactose synthesis rates in short-term tissue cultures. By these criteria, mammary cell differentiation did not change significantly with stage of lactation, but depended on the extent to which the gland was filled with milk. Key enzyme activities and in vitro synthesis rates were significantly higher in glands suckled immediately before tissue collection, compared with contralateral glands that were engorged with milk. This indicates that mammary cell differentiation in the lactating bat is regulated locally within each gland by a mechanism sensitive to milk accumulation, to the extent that, unlike other species, this obscures any underlying effect of stage of lactation.
通过测定关键酶活性，以及在短期组织培养中测定蛋白质和乳糖合成速率，对正在泌乳的伏翼蝠（ Pipistrellus pipistrellus ）的乳腺细胞分化进行了测量。根据这些标准，乳腺细胞分化并未随泌乳阶段而发生显著变化，而是取决于腺体充满乳汁的程度。与充满乳汁的对侧腺体相比，在采集组织前立即哺乳的腺体中，关键酶活性和体外合成速率显著更高。这表明，泌乳蝙蝠的乳腺细胞分化在每个腺体内受到局部调节，其调节机制对乳汁积累敏感，以至于与其他物种不同，这掩盖了泌乳阶段的任何潜在影响。
