Sharp P A, Debnam E S
Department of Physiology, Royal Free Hospital School of Medicine, London.
Exp Physiol. 1992 Nov;77(6):913-6. doi: 10.1113/expphysiol.1992.sp003658.
Bradykinin has been shown to stimulate sugar uptake by intact intestine, but the cellular locus of this action is unknown. In this study on rat we show that bradykinin (10(-7) M) stimulates both sodium-dependent glucose uptake at the brush-border membrane and carrier-mediated movement across the basolateral membrane of upper villus enterocytes. These results suggest a role for bradykinin in the local control of glucose transport though the mechanisms underlying these effects have still to be elucidated.
缓激肽已被证明可刺激完整肠道对糖的摄取，但其作用的细胞位点尚不清楚。在这项对大鼠的研究中，我们发现缓激肽（10^(-7) M）可刺激刷状缘膜上的钠依赖性葡萄糖摄取以及载体介导的葡萄糖穿过上绒毛肠上皮细胞基底外侧膜的转运。这些结果表明缓激肽在葡萄糖转运的局部调控中发挥作用，尽管这些作用的潜在机制仍有待阐明。
