Jiménez-Mejías M E, Ortiz Leyba C, Jiménez Gonzalo F J, del Nozal M, Campos T, Jiménez Jiménez F J
Unidad de Enfermedades Infecciosas, Hospital Universitario Virgen del Rocío, Sevilla.
Enferm Infecc Microbiol Clin. 1992 Nov;10(9):543-6.
Fungal infections are nowadays more common in clinical practice. The most frequently isolated fungi are Candida and Cryptococcus. Infection due to Rhodotorula mucilaginosa is very uncommon. We describe here our experience with R. mucilaginosa fungemia, with emphasis on total parenteral nutrition related episodes.
A retrospective review identified 3 patients with R. mucilaginosa, and predisposing conditions, clinical features, treatment used and outcome were analyzed. The case definition includes the repeated isolation of R. mucilaginosa in several blood-cultures and/or the isolation of R. mucilaginosa in one single blood culture together with its isolation in any other site.
Three patients were identified. In all of them there are some defects in immune response (skin anergy in two, immunosuppressive therapy in the remaining patient), had an iv line placed, under antibiotic therapy and total parenteral nutrition. All factors could have been related to the development of R. mucilaginosa infection.
Although its pathogenic role is controversial, in two or our patients R. mucilaginosa infections correlates well with clinical signs and symptoms of invasive infections (fever, hemodynamic changes). The treatment is still not clear.
真菌感染如今在临床实践中更为常见。最常分离出的真菌是念珠菌和隐球菌。黏液红酵母感染非常罕见。我们在此描述我们对黏液红酵母菌血症的经验，重点是与全胃肠外营养相关的病例。
通过回顾性研究确定了3例黏液红酵母感染患者，并分析了易感因素、临床特征、治疗方法及结果。病例定义包括在多次血培养中反复分离出黏液红酵母和/或在单次血培养中分离出黏液红酵母并在其他任何部位也分离出该菌。
确定了3例患者。所有患者的免疫反应均存在一些缺陷（2例皮肤无反应性，其余1例接受免疫抑制治疗），均有静脉置管，接受抗生素治疗及全胃肠外营养。所有这些因素都可能与黏液红酵母感染的发生有关。
尽管其致病作用存在争议，但在我们的2例患者中，黏液红酵母感染与侵袭性感染的临床体征和症状（发热、血流动力学改变）密切相关。治疗方法仍不明确。
