Neofytos Dionissios, Horn David, De Simone Joseph A
Division of Infectious Diseases and Environmental Medicine, Thomas Jefferson University Hospital, 125 South 9th Street, Suite 403, Philadelphia, PA 19107, USA.
South Med J. 2007 Feb;100(2):198-200. doi: 10.1097/01.smj.0000254170.72684.cb.
Rhodotorula mucilaginosa (formerly Rhodotorula rubra) is a ubiquitous, environmental, urease-positive yeast that does not ferment sugars and can assimilate various carbohydrates. Characterized by the salmon-pink to coral-red color of its colonies, Rhodotorula mucilaginosa can disseminate and cause significant disease. We present a case of sustained Rhodotorula mucilaginosa catheter-related fungemia in a patient with sickle cell anemia who refused removal of the implanted port. The patient remained clinically stable, with blood cultures persistently growing Rhodotorula mucilaginosa, despite appropriate antifungal therapy. An extensive literature review revealed a wide range of clinical manifestations in immunocompromised patients. Susceptibility patterns to different antifungal agents and therapeutic considerations are thoroughly discussed. Rhodotorula mucilaginosa can be a significant, recalcitrant pathogen in immunocompromised patients and prompt treatment should be instituted.
粘红酵母（以前称为深红酵母）是一种广泛存在于环境中的脲酶阳性酵母，它不发酵糖类，但能同化多种碳水化合物。粘红酵母的菌落呈鲑鱼粉色至珊瑚红色，可播散并引发严重疾病。我们报告了一例镰状细胞贫血患者发生持续性粘红酵母导管相关真菌血症的病例，该患者拒绝拔除植入的端口。尽管进行了适当的抗真菌治疗，但患者临床症状保持稳定，血培养持续培养出粘红酵母。广泛的文献综述显示免疫功能低下患者有多种临床表现。文中还深入讨论了对不同抗真菌药物的药敏模式及治疗注意事项。粘红酵母在免疫功能低下患者中可能是一种重要的、顽固的病原体，应及时进行治疗。
