Gaĭnutdinov M Kh, Konov V V, Ishmukhamedov R N, Zakharova T N, Khalilova M A, Safarov K S
Biokhimiia. 1992 Nov;57(11):1618-26.
Studies of swelling of rat liver mitochondria in isoosmotic solutions of nonelectrolytes in the presence of respiration inhibitors revealed that submicromolar concentrations of Ca2+ increase the diameter of pores in the inner mitochondrial membrane--from 5.5-6.0 A (10(-8) M Ca2+) up to 7.5 A (3 x 10(-7) M Ca2+) and 8.0-8.5 A (6 x 10(-7) M Ca2+); these increases are prevented by cyclosporin A. The inner mitochondrial membrane with an effective pore diameter of 7.5 A is readily permeable for potassium but not for sodium ions, although with an increase in the effective pore diameter up to 8.0-8.5 A the selectivity of the K(+)-Na+ channel decreases. A conclusion is drawn that in the presence of submicromolar concentrations of Ca2+ the conductivity of the cyclosporin-sensitive pore for monovalent cations increases in the following order: K > Na > Li.
在呼吸抑制剂存在的情况下，对大鼠肝线粒体在非电解质等渗溶液中的肿胀研究表明，亚微摩尔浓度的Ca2+会增加线粒体内膜孔的直径——从5.5 - 6.0埃（10^(-8) M Ca2+）增加到7.5埃（3×10^(-7) M Ca2+）以及8.0 - 8.5埃（6×10^(-7) M Ca2+）；这些增加可被环孢菌素A阻止。有效孔径为7.5埃的线粒体内膜对钾离子具有良好的通透性，但对钠离子不通透，尽管随着有效孔径增加到8.0 - 8.5埃，K(+) - Na+通道的选择性会降低。得出的结论是，在亚微摩尔浓度的Ca2+存在时，环孢菌素敏感孔对单价阳离子的传导性按以下顺序增加：K > Na > Li。
