结构域连接和断开对膜内平面双分子反应产率的影响。
Effects of domain connection and disconnection on the yields of in-plane bimolecular reactions in membranes.
作者信息
Melo E C, Lourtie I M, Sankaram M B, Thompson T E, Vaz W L
机构信息
Centro de Tecnologia Química e Biológica-I.S.T., Oeiras, Portugal.
出版信息
Biophys J. 1992 Dec;63(6):1506-12. doi: 10.1016/S0006-3495(92)81735-6.
Abstract
It has recently been shown (Vaz, W.L.C., E.C.C. Melo, and T.E. Thompson. 1989. Biophys. J. 56:869-875; 1990. Biophys. J. 58:273-275) that in lipid bilayer membranes in which ordered and disordered phases coexist, the ordered phase can form a two-dimensional reticular structure that subdivides the coexisting disordered phase into a disconnected domain structure. Here we consider theoretically the yields of bimolecular reactions between membrane-localized reactants, when both the reactants and products are confined to the disordered phase. It is shown that compartmentalization of reactants in disconnected domains can lead to significant reductions in reaction yields. The reduction in yield was calculated for classical bimolecular processes and for enzyme-catalyzed reactions. These ideas can be used to explain certain experimental observations.
摘要
最近有研究表明（瓦斯，W.L.C.，E.C.C. 梅洛，以及T.E. 汤普森。1989年。《生物物理杂志》56:869 - 875；1990年。《生物物理杂志》58:273 - 275），在有序相和无序相共存的脂质双分子层膜中，有序相能够形成一种二维网状结构，该结构将共存的无序相细分为不相连的区域结构。在此，我们从理论上考虑膜定位反应物之间双分子反应的产率，此时反应物和产物都局限于无序相。结果表明，反应物在不相连区域中的区室化会导致反应产率显著降低。针对经典双分子过程和酶催化反应计算了产率的降低情况。这些观点可用于解释某些实验观察结果。
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本文引用的文献
1
Quantitative characterization of the lateral distribution of membrane proteins within the lipid bilayer.脂质双层内膜蛋白侧向分布的定量表征。
Biophys J. 1982 Mar;37(3):617-24.
2
The fluid mosaic model of the structure of cell membranes.细胞膜结构的流动镶嵌模型。
Science. 1972 Feb 18;175(4023):720-31. doi: 10.1126/science.175.4023.720.
3
Lateral diffusion as a rate-limiting step in ubiquinone-mediated mitochondrial electron transport.侧向扩散作为泛醌介导的线粒体电子传递中的限速步骤。
J Biol Chem. 1989 Mar 25;264(9):4978-85.
4
Role of mobility of redox components in the inner mitochondrial membrane.氧化还原成分在线粒体内膜中的流动性作用。
J Membr Biol. 1988 Sep;104(3):193-209. doi: 10.1007/BF01872322.
5
Synthesis, location, and lateral mobility of fluorescently labeled ubiquinone 10 in mitochondrial and artificial membranes.荧光标记的泛醌10在线粒体膜和人工膜中的合成、定位及侧向流动性
Biochemistry. 1989 Apr 18;28(8):3168-76. doi: 10.1021/bi00434a009.
6
Lipid lateral diffusion and membrane organization.
FEBS Lett. 1989 Oct 23;257(1):10-6. doi: 10.1016/0014-5793(89)81774-0.
7
Translational diffusion and fluid domain connectivity in a two-component, two-phase phospholipid bilayer.双组分、两相磷脂双层中的平移扩散和流体域连通性。
Biophys J. 1989 Nov;56(5):869-76. doi: 10.1016/S0006-3495(89)82733-X.
8
The membrane skeleton of erythrocytes. A percolation model.红细胞的膜骨架。一种逾渗模型。
Biophys J. 1990 Jun;57(6):1167-77. doi: 10.1016/S0006-3495(90)82636-9.
9
Fluid phase connectivity in an isomorphous, two-component, two-phase phosphatidylcholine bilayer.同晶型、双组分、两相磷脂酰胆碱双层中的流体相连通性。
Biophys J. 1990 Jul;58(1):273-5. doi: 10.1016/S0006-3495(90)82373-0.
10
Fluid-phase connectivity and translational diffusion in a eutectic, two-component, two-phase phosphatidylcholine bilayer.共晶、双组分、两相磷脂酰胆碱双层中的液相连通性和平动扩散
Biochemistry. 1991 Jun 4;30(22):5573-9. doi: 10.1021/bi00236a033.
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