Parkinson E K
Beatson Institute for Cancer Research, Bearsden, Glasgow, UK.
Semin Cell Biol. 1992 Dec;3(6):435-44. doi: 10.1016/1043-4682(92)90014-m.
The epidermis is a stratified epithelium consisting of interfollicular regions and appendages (hair follicles, sweat glands, sebaceous glands). The dominant cell type (the keratinocyte) is arranged in groups of cells termed epidermal proliferative units (EPUs), and one centrally-located clonogenic stem cell is ultimately responsible for replacing the remainder of the cells in the unit. Evidence is reviewed which indicates that the epidermal Langerhans' cell (ELC), and the cells comprising the dermis, may modify the keratinocyte microenvironment to create stem cell 'niches' and cellular diversity within the basal layer.
表皮是一种复层上皮，由毛囊间区域和附属器（毛囊、汗腺、皮脂腺）组成。主要的细胞类型（角质形成细胞）以称为表皮增殖单位（EPU）的细胞群形式排列，一个位于中央的克隆性干细胞最终负责替换该单位中的其余细胞。本文综述了相关证据，这些证据表明表皮朗格汉斯细胞（ELC）以及构成真皮的细胞可能会改变角质形成细胞的微环境，从而在基底层内形成干细胞“龛”和细胞多样性。
