Levy M
Department of Physiology, McGill University, Montréal, Quebec, Canada.
Can J Physiol Pharmacol. 1992 Oct;70(10):1432-5. doi: 10.1139/y92-201.
It has been reported that the intraportal infusion of glutamine in Munich-Wistar rats will cause depression of renal perfusion and the urinary excretion of salt and water. We have attempted to reproduce these findings in anaesthetized dogs. L-Glutamine was infused at doses between 120 and 150 mumol/min into the portal vein and femoral vein of anaesthetized dogs. No effect was observed on portal venous pressure, blood pressure, or kidney function. Similar data were obtained with D-glutamine. Liver biopsy revealed no abnormalities. When 1.5-3 micrograms histamine (free base) was infused into the portal system, portal venous pressure rose from 15.2 +/- 0.33 to 24.8 +/- 0.40 cmH2O (p < 0.05) (1 cmH2O = 98.1 Pa). Glutamine infusions do not appear to initiate hepatorenal reflexes in dogs as they have been reported to do in rats.
据报道，在慕尼黑-威斯塔大鼠中门静脉内输注谷氨酰胺会导致肾灌注以及盐和水的尿排泄减少。我们试图在麻醉犬中重现这些发现。将L-谷氨酰胺以120至150微摩尔/分钟的剂量注入麻醉犬的门静脉和股静脉。未观察到对门静脉压力、血压或肾功能有影响。用D-谷氨酰胺获得了类似的数据。肝活检未发现异常。当将1.5 - 3微克组胺（游离碱）注入门静脉系统时，门静脉压力从15.2±0.33厘米水柱升至24.8±0.40厘米水柱（p<0.05）（1厘米水柱 = 98.1帕斯卡）。谷氨酰胺输注似乎不会像在大鼠中报道的那样在犬中引发肝肾反射。
