Finger H, Wirsing von König C H
Institut für Hygiene, Städtische Krankenanstalten Krefeld.
Immun Infekt. 1992 Dec;20(6):188-91.
Each vaccine is normally rated according to its efficacy and to the frequency and severity of unwanted side effects. The efficacy of whole-cell pertussis vaccines is beyond doubt, its frequent side effects, however, stimulated research into less reactogenic acellular vaccines. Several acellular pertussis vaccines of different composition have been developed. All of these produced significantly less local and systemic side effects, as compared to the conventional whole-cell vaccine. Various epidemiological data strongly suggest the efficacy of these vaccines. An equivalence of protective efficacy between whole-cell vaccines and acellular pertussis vaccines can, however, only be documented in controlled field trials, which are now ongoing in several countries.
每种疫苗通常根据其效力以及不良反应的发生频率和严重程度进行评级。全细胞百日咳疫苗的效力毋庸置疑，然而，其频繁的副作用促使人们对反应原性较低的无细胞疫苗展开研究。现已研发出几种成分不同的无细胞百日咳疫苗。与传统的全细胞疫苗相比，所有这些疫苗产生的局部和全身副作用都明显更少。各种流行病学数据有力地表明了这些疫苗的效力。然而，全细胞疫苗和无细胞百日咳疫苗之间的保护效力等效性，只有在几个国家正在进行的对照现场试验中才能得到证明。
