Teichmann G
University of Rostock, Department of Internal Medicine, Germany.
Int J Clin Pharmacol Ther Toxicol. 1992 Nov;30(11):419-20.
In 1636, the Rostock professor of medicine and the art of poetry, Peter Lauremberg (1585-1639), was one of the earliest to mention circulation which had been discovered by William Harvey and documented in his anatomical manual. In 1628 William Harvey proved the existence of the blood circulation by calculating the "cardiac output in a half an hour (semihora)". The answer to the question why Harvey chose half an hour as the time range can be found in the way of measuring time usual at that period. The sandglasses were turned half-hourly in maritime navigation and the wheel-clocks on shore had only the hour-hand. Improved chronometry was one of the prerequisites for measuring cardiac output. The minute-hand became usual after 1700 and the second-hand later on. Taking into consideration the alterations of cardiac output made the latter one of the most important circulation parameters in diagnostics, prognostication and therapeutics.
1636年，罗斯托克的医学与诗歌艺术教授彼得·劳伦贝格（1585 - 1639）是最早提及血液循环的人之一，血液循环由威廉·哈维发现并记录在他的解剖学手册中。1628年，威廉·哈维通过计算“半小时内心输出量”证明了血液循环的存在。关于哈维为何选择半小时作为时间范围这一问题的答案，可以从那个时期常用的计时方式中找到。在海上航行中，沙漏每半小时翻转一次，而岸上的轮钟只有时针。精密计时法的改进是测量心输出量的先决条件之一。分针在1700年之后才普遍使用，秒针则更晚。考虑心输出量的变化使其成为诊断、预后和治疗中最重要的循环参数之一。
