实验性腹水中白蛋白和球蛋白的循环；用C14标记蛋白质研究血浆与腹水之间的相对交换率。
Albumin and globulin circulation in experimental ascites; relative rates of interchange between plasma and ascitic fluid studied with C14-labeled proteins.
作者信息
McKEE F W, YUILE C L, LAMSON B G, WHIPPLE G H
出版信息
J Exp Med. 1952 Feb;95(2):161-72. doi: 10.1084/jem.95.2.161.
Abstract
Plasma containing carbon(14)-labeled albumin and globulin, obtained by feeding epsilon-C(14)D,L.-lysine to a donor dog, has been injected intravenously and intraperitoneally into recipient dogs with experimental ascites. The circulation and interchange of total plasma protein between circulating blood and ascitic fluid have been confirmed and the participation of both albumin and globulin in this interchange has been demonstrated. Labeled albumin tends to reach equilibrium in plasma and ascitic fluid in a shorter period of time (1 to 2 days) than does globulin (2 or more days), after administration of labeled plasma by either route. Evidence is presented that the rate of transfer of albumin across the peritoneal membrane is at least three times faster than that of globulin in terms of weight.
摘要
通过给供体犬喂食ε-C(14)D,L-赖氨酸获得的含有碳(14)标记白蛋白和球蛋白的血浆，已通过静脉内和腹腔内注射到患有实验性腹水的受体犬体内。已证实循环血液和腹水之间总血浆蛋白的循环和交换，并且已证明白蛋白和球蛋白都参与了这种交换。通过任何一种途径给予标记血浆后，标记白蛋白比球蛋白（2天或更长时间）在更短的时间内（1至2天）趋于在血浆和腹水中达到平衡。有证据表明，就重量而言，白蛋白跨腹膜的转移速率至少比球蛋白快三倍。
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