Roberts M C, Leonard R B, Briselden A, Schoenknecht F D, Coyle M B
Department of Pathobiology, University of Washington, Seattle 98195.
J Antimicrob Chemother. 1992 Oct;30(4):463-74. doi: 10.1093/jac/30.4.463.
Antibiotic-resistant Corynebacterium strains were isolated from 14 Harborview and one Veterans Administration Hospital patients in Seattle during the period 1987-90. These clindamycin-erythromycin resistant strains were shown to hybridize with the ermCd gene, which was cloned from a Corynebacterium diphtheriae plasmid and encodes for a rRNA methylase. Thirteen of these strains also hybridized with the tetM gene probes, and were tetracycline resistant. The ermCd gene could be transferred, by conjugation, while the tetM gene was not transferable.
1987年至1990年期间，在西雅图的14名哈博维尤医疗中心和1名退伍军人管理局医院的患者中分离出了耐抗生素棒状杆菌菌株。这些对克林霉素和红霉素耐药的菌株被证明可与ermCd基因杂交，该基因是从白喉棒状杆菌质粒中克隆出来的，编码一种rRNA甲基化酶。其中13株菌株也可与tetM基因探针杂交，并且对四环素耐药。ermCd基因可通过接合进行转移，而tetM基因则不可转移。
