黏液癌相关抗原（MCA）检测在乳腺癌中的诊断价值。

The diagnostic value of mucinous carcinoma-associated antigen (MCA) tests in breast carcinomas.

作者信息

Günes I, Miserez A R, Müller-Brand J, Maecke H

机构信息

Department of Nuclear Medicine, Uludağ University Hospital, Bursa, Turkey.

出版信息

Int J Biol Markers. 1992 Oct-Dec;7(4):222-4. doi: 10.1177/172460089200700403.

DOI:10.1177/172460089200700403

PMID:1491177

Abstract

MCA (Mucinous Carcinoma-Associated Antigen) levels of 176 breast carcinoma patients were tested postoperatively by serial determination. One hundred forty-one patients had non-progressive disease (PD-) while 35 were in the progressive phase (PD+); in the latter the diagnosis was confirmed by means of current diagnostic procedures. One hundred seventeen of the 141 PD-patients showed MCA levels below cutoff whereas 27 of the 35 PD+ cases showed high values. The difference in the incidence of elevated MCA levels between PD- and PD+ groups was statistically significant (p < 0.05). The overall diagnostic efficacy of MCA assays showed 77% sensitivity and 82% specificity.

摘要

对176例乳腺癌患者术后进行连续检测，以测定MCA（黏液癌相关抗原）水平。141例患者病情无进展（PD-），35例处于疾病进展期（PD+）；后者通过当前诊断程序确诊。141例PD-患者中，117例MCA水平低于临界值，而35例PD+患者中有27例MCA水平较高。PD-组和PD+组MCA水平升高的发生率差异具有统计学意义（p < 0.05）。MCA检测的总体诊断效能显示，敏感性为77%，特异性为82%。