关于线性开放单室模型中速率常数相对大小的评估。 - Suppr | 超能文献

On the assessment of the relative magnitude of rate constants in the linear open one-compartment model.

作者信息

Macheras P, Symillides M, Reppas C

出版信息

J Pharm Sci. 1992 Dec;81(12):1231-3. doi: 10.1002/jps.2600811223.

DOI:10.1002/jps.2600811223

Abstract

摘要

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引用本文的文献

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Multiple solutions, illegal parameter values, local minima of the sum of squares, and anomalous parameter estimates in least-squares fitting of the two-compartment pharmacokinetic model with absorption.具有吸收的二室药代动力学模型的最小二乘拟合中的多种解、非法参数值、平方和的局部最小值以及异常参数估计值。

J Pharmacokinet Biopharm. 1996 Feb;24(1):79-101. doi: 10.1007/BF02353511.

2

Simplified methods for the evaluation of the parameters of the time course of plasma concentration in the one-compartment body model with first-order invasion and first-order drug elimination including methods for ascertaining when such rate constants are equal.单室体内模型中具有一级吸收和一级药物消除的血浆浓度时程参数评估的简化方法，包括确定这些速率常数何时相等的方法。

J Pharmacokinet Biopharm. 1993 Dec;21(6):689-734. doi: 10.1007/BF01113501.

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The Bateman function revisited: a critical reevaluation of the quantitative expressions to characterize concentrations in the one compartment body model as a function of time with first-order invasion and first-order elimination.重新审视贝特曼函数：对单室体内模型中作为时间函数的浓度进行定量表达的批判性重新评估，该模型具有一级侵入和一级消除过程。

J Pharmacokinet Biopharm. 1994 Apr;22(2):103-28. doi: 10.1007/BF02353538.