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多毛症女性的尿液类固醇谱(作者译)

[Urine steroid profiles of hirsute women (author's transl)].

作者信息

Egger H J, Reiner J, Spiteller G

出版信息

J Chromatogr. 1978 May 1;145(3):359-69.

PMID:149138
Abstract

Steroid profiles of women suffering from idiopathic hirsutism show in more than 50% of the cases of 10--100 fold increase in the excretion of dehydroepiandrosterone (DHEA) compared with normal values. The excretion of DHEA was reduced much more than that of other 17-ketosteroids if the adrenals (NNR) were suppressed by dexamethasone (DXM). Within one week they reached values at the compound noise level of the gas chromatograms. If the ovaries were stimulated with human chorionic gonadotropin during continued suppression of the NNR with DXM no increase of DHEA could be detected.

摘要

患有特发性多毛症的女性的类固醇谱显示,在超过50%的病例中,脱氢表雄酮(DHEA)的排泄量比正常值增加了10至100倍。如果用地塞米松(DXM)抑制肾上腺(NNR),DHEA的排泄量比其他17-酮类固醇减少得更多。一周内,它们达到了气相色谱图复合噪声水平的值。如果在持续用DXM抑制NNR的过程中用人绒毛膜促性腺激素刺激卵巢,则未检测到DHEA增加。

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