Dahl M, Chalmers A, Wade J, Calverley D, Munt B
Department of Medicine, University of British Columbia, Vancouver, Canada.
J Rheumatol. 1992 Nov;19(11):1807-9.
Pulmonary hypertension is the most frequent cause of death in patients with mixed connective tissue disease. The pulmonary hypertension is progressive and difficult to treat effectively. These patients experience considerable morbidity secondary to diminished cardiac function. We describe a case in which sequential administration of cyclophosphamide and cyclosporine A favorably altered the clinical and hemodynamic course of this serious complication.
肺动脉高压是混合性结缔组织病患者最常见的死亡原因。肺动脉高压呈进行性发展且难以有效治疗。这些患者因心功能减退而出现相当程度的发病情况。我们描述了一例病例，其中序贯给予环磷酰胺和环孢素A有利地改变了这一严重并发症的临床和血流动力学进程。
