Doi T
Department of Geriatric Medicine, Faculty of Medicine, Kyoto University.
Nihon Rinsho. 1992 Dec;50(12):2849-54.
In the present report, we have used transgenic models to analyze the role of growth factors in the development of glomerulosclerosis. All peptides inducing a growth response do not lead to glomerulosclerosis, however, several transgenic models including growth hormone, transforming growth factor-a or SV 40T antigen developed progressive glomerulosclerosis, which was associated with glomerular hypertrophy. Evidence obtained from these transgenic models suggests that glomerulosclerosis may be related to a dysregulation of glomerular cell growth and a synthesis of extracellular matrix components by resident glomerular cells.
在本报告中，我们使用转基因模型来分析生长因子在肾小球硬化发展中的作用。然而，并非所有诱导生长反应的肽都会导致肾小球硬化，包括生长激素、转化生长因子-α或SV40T抗原在内的几种转基因模型出现了进行性肾小球硬化，这与肾小球肥大有关。从这些转基因模型中获得的证据表明，肾小球硬化可能与肾小球细胞生长失调以及驻留肾小球细胞合成细胞外基质成分有关。
