Matsuzaki K, Koide K
Internal Medicine III, Teikyo University School of Medicine.
Nihon Rinsho. 1992 Dec;50(12):2949-55.
Steroid hormones such as mineralo- and glucocorticoids act as important regulators for the kidney to maintain the body fluid homeostasis. During the past 40 years, numerous investigations have been dedicated to the elucidation of precise mechanisms of steroid hormone actions in their target tissues including the kidney. Now it is well recognized that cellular actions of steroid hormones can be accomplished by two step processes, namely a specific receptor binding in the cytosol and/or the nucleus and a new protein synthesis through a gene transcription. The efforts for the isolation and purification of steroid hormone receptors have been also made and followed by the great successes of molecular techniques in the cDNA cloning and determination of amino acid sequences for them in recent years. The revealed high homology of the functional domains of receptors has renewed the issues of how tissue specificities of steroid hormone actions are determined. The identification of steroid-induced proteins and cellular steroid hormone metabolites would be also important issues to be studied.
盐皮质激素和糖皮质激素等类固醇激素是肾脏维持体液平衡的重要调节因子。在过去的40年里，众多研究致力于阐明类固醇激素在其靶组织（包括肾脏）中的精确作用机制。现在人们已经清楚地认识到，类固醇激素的细胞作用可以通过两个步骤来完成，即与细胞质和/或细胞核中的特定受体结合，以及通过基因转录进行新的蛋白质合成。人们也一直在努力分离和纯化类固醇激素受体，近年来分子技术在cDNA克隆和确定它们的氨基酸序列方面取得了巨大成功。受体功能域的高度同源性重新引发了关于如何确定类固醇激素作用的组织特异性的问题。鉴定类固醇诱导蛋白和细胞类固醇激素代谢物也是有待研究的重要问题。
