Colella G, Itro A, Corvo G
Istituto di Chirurgia Orale e Maxillo Facciale, I Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II.
Minerva Stomatol. 1992 Sep;41(9):417-20.
The authors describe a clinical case observed at the Inst of Oral & Maxillofacial Surgery characterized by three simultaneous symptoms: arterious hypertension, diabetes mellitus, oral erosive lichen planus. Grinspan & his co-workers observed this syndrome. The results of their research were exposed at the Congress on Dermatology in Buenos Aires, 1963. In 1965 in a repetitive study Grupper & Avul seemed confirm the existence of this symptomatological triad; therefore the authors defined this complex as "Grinspan's syndrome". Further researches conducted by other authors (Jolly, Powell. Howell e Rick) confirmed the association hypertension-diabetes-"erosive" lichen. However there were other worthwhile studies (Lozada-Nur, Christensen) which emphasized a not significant high frequency of patients with diabetes and high blood pressure and the oral sugar tolerance like random specimens of common people. Besides the authors notice that their clinical case is interesting not only because of their simultaneous presence of the three symptoms but also because of the bioptic appearance of a cancer likely appeared on a pre-existing inveterate lichenoid lesion.
作者描述了一例在口腔颌面外科研究所观察到的临床病例，其特征为同时出现三种症状：动脉高血压、糖尿病、口腔糜烂性扁平苔藓。格林斯潘及其同事观察到了这种综合征。他们的研究结果在1963年布宜诺斯艾利斯皮肤科大会上公布。1965年，格鲁珀和阿武尔在一项重复性研究中似乎证实了这种症状三联征的存在；因此，作者将这种综合征定义为“格林斯潘综合征”。其他作者（乔利、鲍威尔、豪厄尔和里克）进行的进一步研究证实了高血压-糖尿病-“糜烂性”扁平苔藓之间的关联。然而，还有其他有价值的研究（洛萨达-努尔、克里斯蒂安森）强调，糖尿病和高血压患者以及口服糖耐量情况与普通人随机样本相比，其频率并无显著升高。此外，作者指出，他们的临床病例之所以有趣，不仅是因为三种症状同时出现，还因为在先前存在的慢性苔藓样病变上可能出现了癌症的活检表现。
