Massacesi M, Milkowski M, Gianfranceschi C, Massacesi L
Divisione di Ostetricia e Ginecologia, Ospedale Civile di Senigallia, Ancona.
Minerva Ginecol. 1992 Dec;44(12):641-4.
A short term therapy of leiomyomata uteri with leuprolide acetate depot 3.75 i.m. every 28 days for 4 months was started in 19 patients. Uterine volume, based on the ultrasound data, was calculated, utilizing the formula for a prolate ellipsoid, before and after treatment. Before the treatment the uterine mean volume was 207.3 cc and decreased to 122.2 cc after therapy. The efficacy of the treatment was evaluated by means of the "t" test for paired data and showed a p < 0.002.
