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低风险子宫内膜增生的诊断与治疗。促性腺激素释放激素类似物的应用经验

[Diagnosis and therapy of low-risk endometrial hyperplasia. Experience with LH-RH-A].

作者信息

Pace S, Stentella P, Frega A, Palazzetti P L, Nobili F, Figliolini M, Grassi A

机构信息

II Clinica Ostetrica e Gineologica, Università degli Studi di Roma La Sapienza.

出版信息

Minerva Ginecol. 1992 Dec;44(12):645-51.

PMID:1491773
Abstract

Endometrial hyperplasia is a endometrial condition often found in perimenopausal age. AUB is the most frequent symptom of endometrial hyperplasia. The combination of hysteroscopy and endometrial biopsy is the most suitable approach for the diagnosis of endometrial hyperplasia in symptomatic patients. The Authors have studied endometrial modifications due to LH-RH analogue, a depot formula, in 60 perimenopausal patients with AUB and with hysteroscopic and histologic picture of low-risk endometrial hyperplasia. They report the result of treatment efficacy (disappearance of symptoms and tendency to hypoatrophy of the mucosa). The use of LH-RH A seems to have a good result in the management of oestrogen-dependent gynaecological benign diseases.

摘要

子宫内膜增生是一种常见于围绝经期的子宫内膜病症。异常子宫出血是子宫内膜增生最常见的症状。宫腔镜检查和子宫内膜活检相结合是诊断有症状患者子宫内膜增生最合适的方法。作者研究了长效剂型促性腺激素释放激素(LH-RH)类似物对60例有异常子宫出血且宫腔镜和组织学表现为低风险子宫内膜增生的围绝经期患者子宫内膜的影响。他们报告了治疗效果(症状消失以及黏膜趋向萎缩)。促性腺激素释放激素类似物(LH-RH A)的使用在雌激素依赖性妇科良性疾病的治疗中似乎有良好效果。

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