Koonin E V, Gorbalenya A E
Institute of Microbiology, Academy of Sciences, Moscow, Russian Federation.
Protein Seq Data Anal. 1992;5(1):43-5.
It is demonstrated that the amino acid sequences of the products of E. coli genes sbcC and prrC, and bacteriophage P2 gene old encompass the four conserved motifs typical of the superfamily of UvrA-related ATPases. A more pronounced statistically significant similarity was revealed between SbcC protein, bacteriophage T4 endonuclease component gp46 and bacteriophage T5 protein D13. It is suggested that the newly identified members of the superfamily might all be ATPase components of the respective nucleases, and that the reactions catalyzed by these enzymes are probably ATP dependent.
已证明大肠杆菌基因sbcC和prrC的产物以及噬菌体P2基因old的氨基酸序列包含UvrA相关ATP酶超家族典型的四个保守基序。在SbcC蛋白、噬菌体T4内切核酸酶组分gp46和噬菌体T5蛋白D13之间发现了更显著的统计学上的相似性。有人提出，这个超家族新鉴定出的成员可能都是各自核酸酶的ATP酶组分，并且这些酶催化的反应可能依赖于ATP。
