Haber J E
Rosenstiel Center, Brandeis University, Waltham, MA 02254.
Trends Genet. 1992 Dec;8(12):446-52. doi: 10.1016/0168-9525(92)90329-3.
The study of yeast mating-type (MAT) gene switching has provided insights into several aspects of the regulation of gene expression. MAT switching is accomplished by a highly programmed site-specific homologous recombination event in which mating-type-specific sequences at MAT are replaced by alternative DNA sequences copied from one of two unexpressed donors. The mating-type system has also provided an opportunity to study both the genetic regulation of gene silencing by alterations in chromatin structure, and the basis of preferential recombination between a recipient of genetic information and one of several possible donors.
对酵母交配型（MAT）基因转换的研究为基因表达调控的多个方面提供了见解。MAT转换是通过一个高度程序化的位点特异性同源重组事件完成的，在这个事件中，MAT处的交配型特异性序列被从两个未表达的供体之一复制的替代DNA序列所取代。交配型系统还提供了一个机会，来研究染色质结构改变对基因沉默的遗传调控，以及遗传信息受体与几个可能供体之一之间优先重组的基础。
