[接受中高剂量和高剂量甲氨蝶呤治疗的儿童脑脊液中甲氨蝶呤水平]
[Cerebrospinal fluid methotrexate level in children treated with medium-high and high doses of the drug].
作者信息
Wysocki M, Balcar-Boroń A, Krzyzanowski M, Szadujkis-Szadurski L, Ozyński T, Nowaczyk-Michalak A
机构信息
Katedry i I Kliniki Chorób Dzieci A.M., Bydgoszczy.
出版信息
Acta Haematol Pol. 1992;23(3):185-90.
Concentrations of MTX were determined in the cerebrospinal fluid (csf) and serum after intravenous infusion of MTX at intermediate dose (0.5-1.0 g/m2) and at high dose (5.0 g/m2) to 20 children (33 infusions) with ALL/NHL. The cytotoxic concentrations of MTX in csf (> 1.0 microM/l) were reached in half of the cases after the infusion of MTX at intermediate dose and in all patients after the infusion of 5.0 g/m2. Great inpatient and interpatient variations of MTX concentrations in csf were observed. No statistically significant difference was found between mean systemic clearance of MTX in patients with MTXcsf concentrations > 1.0 microM/l and < 1.0 microM/l after infusion of MTX at intermediate dose.
对20例急性淋巴细胞白血病/非霍奇金淋巴瘤（ALL/NHL）患儿（共33次输注）静脉输注中等剂量（0.5 - 1.0 g/m²）和高剂量（5.0 g/m²）的甲氨蝶呤（MTX）后，测定其脑脊液（CSF）和血清中的MTX浓度。输注中等剂量MTX后，半数病例的脑脊液中MTX达到细胞毒性浓度（> 1.0 μmol/L），而输注5.0 g/m²后所有患者均达到该浓度。观察到脑脊液中MTX浓度在住院患者和患者之间存在很大差异。中等剂量MTX输注后，脑脊液中MTX浓度> 1.0 μmol/L和< 1.0 μmol/L的患者，其MTX的平均全身清除率无统计学显著差异。
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