Schmidt E B, Varming K, Svaneborg N, Dyerberg J
Department of Medicine, Aalborg Hospital, Denmark.
Ann Nutr Metab. 1992;36(5-6):283-7. doi: 10.1159/000177731.
The effect of n-3 fatty acids in 11 men with hypertriglyceridaemia was investigated. The subjects were given daily supplements with three different doses of n-3 fatty acids for 8-week periods. The supplements given were 2, 4 and 9 g of n-3 fatty acids/day, respectively. Total cholesterol, triglycerides and the ratio of total cholesterol to HDL-cholesterol significantly decreased with all three doses in a dose-dependent way. HDL-cholesterol increased in a dose-dependent fashion, while apolipoproteins A1 and B were unaltered by the supplements apart from a small increase in apolipoprotein A1 after the lowest dose of n-3 fatty acids. The greatest effect was observed after 2 g of n-3 fatty acids/day.
研究了n-3脂肪酸对11名高甘油三酯血症男性的影响。受试者每天服用三种不同剂量的n-3脂肪酸补充剂，为期8周。所给予的补充剂分别为每天2克、4克和9克n-3脂肪酸。总胆固醇、甘油三酯以及总胆固醇与高密度脂蛋白胆固醇的比率随所有三种剂量均呈剂量依赖性显著降低。高密度脂蛋白胆固醇呈剂量依赖性增加，而载脂蛋白A1和B除了在最低剂量的n-3脂肪酸后载脂蛋白A1略有增加外，不受补充剂影响。每天服用2克n-3脂肪酸后观察到的效果最为显著。
