与鹦鹉热病毒（6BC株）生长相关的因素。I. 蝶酰谷氨酸、维生素B12和亚叶酸。
Factors related to the growth of psittacosis virus (strain 6BC). I. Pteroylglutamic acid, vitamin B12, and citrovorum factor.
作者信息
MORGAN H R
出版信息
J Exp Med. 1952 Mar;95(3):269-76. doi: 10.1084/jem.95.3.269.
The inhibitory action of sodium sulfadiazine on the growth of psittacosis virus (6BC) in embryonated eggs is readily reversed by citrovorum factor but not by small amounts of vitamin B(12). In embryonated eggs, the pteroylglutamic acid analogues, 9-methylpteroylglutamic acid and 4-aminopteroylaspartic acid, produced some suppression of the growth of psittacosis virus (6BC). 4-Aminopteroylglutamic add, 4-amino-N(10)-methylpteroylglutamic acid, and 4-aminopteroylaspartic acid inhibited the growth of this virus in tissue cultures at concentrations which were not toxic for the host tissue. The inhibitory action of 4-amino-N(10)-methylpteroylglutamic acid and 4-aminopteroylaspartic acid was readily overcome by addition of citrovorum factor. Growth of meningopneumonitis virus in embryonated eggs or tissue culture is suppressed by 4-aminopteroylaspartic acid. The advantages of the tissue culture technic for studies on the growth of viruses are discussed.
磺胺嘧啶钠对鹦鹉热病毒（6BC）在鸡胚中生长的抑制作用可被亚叶酸因子轻易逆转，但少量维生素B₁₂不能逆转。在鸡胚中，蝶酰谷氨酸类似物9-甲基蝶酰谷氨酸和4-氨基蝶酰天冬氨酸对鹦鹉热病毒（6BC）的生长有一定抑制作用。4-氨基蝶酰谷氨酸、4-氨基-N(¹⁰)-甲基蝶酰谷氨酸和4-氨基蝶酰天冬氨酸在对宿主组织无毒的浓度下能抑制该病毒在组织培养中的生长。加入亚叶酸因子可轻易克服4-氨基-N(¹⁰)-甲基蝶酰谷氨酸和4-氨基蝶酰天冬氨酸的抑制作用。4-氨基蝶酰天冬氨酸可抑制脑膜肺炎病毒在鸡胚或组织培养中的生长。文中讨论了组织培养技术在病毒生长研究中的优势。
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